Diagnostic Value of KL-6 in ILD

  • End date
    Dec 25, 2023
  • participants needed
  • sponsor
    Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Updated on 25 January 2021
pulmonary disease
pulmonary fibrosis
diagnostic procedures
respiratory disease
interstitial lung disease


KL-6 may be a useful biomarker in patients with interstitial lung disease, but there is limited information in non-Asian populations. Therefore, it is necessary to carry out studies in other populations to confirm the diagnostic values of the biomarker and its prognostic implication.

Hypothesis KL-6 may be a useful biomarker in the management of interstitial lung diseases. But it is necessary to know more about its utility in the European population.

Study Objectives:

  • To determine the concentration of KL-6 in serum of patients with pulmonary fibrosis at the time of diagnosis compared to patients without pulmonary fibrosis
  • Diagnostic yield of KL-6 in patients with pulmonary fibrosis.
  • Correlation of KL-6 values with functional and radiological parameters of disease severity at diagnosis.
  • Correlation of serum KL-6 values with the evolution of the disease.

Condition Pulmonary Disease, Lung Disease, Pulmonary Fibrosis, Pulmonary Fibrosis, Lung Disease, lung fibrosis
Treatment KL-6 levels
Clinical Study IdentifierNCT03103191
SponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Last Modified on25 January 2021


Yes No Not Sure

Inclusion Criteria

Subjects older than 18 years
Chronic respiratory diseases )including Fibrotic interstitial lung disease, asthma or COPD) related or not to a connective tissue disease
Acceptance of the patient to participate in the study by signing the informed consent after having discussed with the researchers the objectives, risks and potential benefits

Exclusion Criteria

Absence of informed consent
Psychiatric disorder or limitation of collaboration (including language, socio-cultural problem, etc.)
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