Studying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa

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  • participants needed
  • sponsor
    Beirut Eye Specialist Hospital
Updated on 21 January 2021


The purpose of this study is to evaluate the effect of L-Dopa on the progression of retinitis pigmentosa.


Retinitis pigmentosa is a group of progressive hereditary diseases that diffusely affects the functioning of photoreceptors and the pigment epithelium. It may be speculated that a protective effect on the pigment epithelium, as it is supposed for L-Dopa, can slow the progression of the disease or even lead to an, at least transient, improvement of visual functions. To evaluate the effect of L-Dopa on retinitis pigmentosa progression, visual acuity, electroretinogram and visual field will be preformed regularly.

Condition Retinitis Pigmentosa
Treatment levodopa-carbidopa
Clinical Study IdentifierNCT02837640
SponsorBeirut Eye Specialist Hospital
Last Modified on21 January 2021


Yes No Not Sure

Inclusion Criteria

All confirmed cases of retinitis pigmentosa
VA of 20/400 or better

Exclusion Criteria

Advanced stages of retinitis pigmentosa with poor best corrected visual acuity (less than 20/400)
co-existing eye morbidities interfering with retinitis pigmentosa (glaucoma, retinal detachment...)
Flat electroretinogram
Intolerance or counterindication to drug
Unability for long-term follow-up
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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