Last updated on February 2019

Potential Benefit of the Combination of Metamizole and Ibuprofen After Third Lower Molar Extraction


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Postoperative pain
  • Age: Between 18 - 60 Years
  • Gender: Male or Female

Inclusion Criteria:

  • planned sequential both-sided lower third molar extraction (split-mouth) with osteotomy (with or without upper molar extraction in local anesthesia)
  • able to understand the study and the NRS scale

Exclusion Criteria:

  • simultaneous both sided extraction or only upper third molar extraction
  • general anesthesia
  • known or presumed abnormal coagulation status
  • known or presumed liver or renal dysfunction
  • contraindication against metamizole known or suspected (known or suspected allergy against novalgin or other pyrazolones, anaphylactic reaction against NSAIDS, decreased bone marrow function or hematopoesis, hepatic porphyria, glucose-6-phosphate dehydrogenase deficiency, and pregnancy/breastfeeding)
  • contraindication against ibuprofen (known or suspected allergy against ibuprofen, anaphylactic reaction against Nonsteroidal anti-inflammatory drugs (NSAID), active or recurrent stomach or duodenal ulcera or bleeding, severe liver or renal insufficiency, inflammatory bowel syndrome, and pregnancy/breastfeeding)
  • pregnancy and breast feeding mothers

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.