Esmolol Versus Dexmedetomidine During Intracranial Procedures

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    George Papanicolaou Hospital
Updated on 21 January 2021


Patients undergoing intracranial procedures may experience severe hypertension and tachycardia due to intracranial hypertension and to increased release of adrenaline. Preventing perioperative sympathetic activity is of great importance. A common technique is using b-blockers like esmolol, which effectively block perioperative hemodynamic changes during intracranial surgery. A2 agonists, like Dexmedetomidine-Dex are now being used as a component of a balanced anesthesia during neurosurgical procedures. This study aimed to evaluate whether esmolol or dex attenuates perioperative changes in patients undergoing elective craniotomy with fast track neuroanesthesia.


Patients scheduled for elective craniotomy are randomized to receive Dex 1/Kg over 10 minutes following by continuous infusion of Dex 0.7/Kg (group D) or esmolol 500mcg/Kg over 5 min following by continuous infusion of 300mcg/Kg/min (group E). Patients in both groups are subjected to a standardized anesthesia comprising of induction with propofol, fentanyl, rocuronium, and maintained with Oxygen-air: 1/1, sevoflurane and bolus fentanyl in order to access the same level of anesthesia (BIS 40-50). The hemodynamic variables at various stages of surgery (HR-heart rate, MAP-Mean arterial pressure) and recovery characteristics are also recorded. It is also performed monitoring of cerebral oximetry (INVOS).

Condition Berry Aneurysm, Malignant neoplasm of brain
Treatment Dexmedetomidine, Esmolol
Clinical Study IdentifierNCT02563288
SponsorGeorge Papanicolaou Hospital
Last Modified on21 January 2021

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