Serial, Non-invasive Analysis of Exhaled Breath Condensate in Ventilated Trauma Patients

  • STATUS
    Recruiting
  • End date
    Dec 17, 2022
  • participants needed
    350
  • sponsor
    Vanderbilt University Medical Center
Updated on 24 February 2022

Summary

To determine if the analysis of exhaled breath condensate correlates with the development & resolution of pneumonia.

Description

This proposal investigates the utility of exhaled breath condensate fluid (EBCF) collected from heat moisture exchange (HME) filters connected to patient's endotracheal tubes for early, non-invasive detection of ventilator-associated pneumonia (VAP) in critically ill or injured ICU patients. The development of pneumonia during mechanical ventilation is the most common healthcare-associated infection in severely injured patients, accounting for substantial morbidity, excess ICU and hospital stay, additional cost and increased mortality.

Details
Condition Ventilator Associated Pneumonia (VAP)
Treatment molecular analysis of exhaled breath condensate, molecular analysis of mini-bronchoalveolar lavage (BAL) aspirate, molecular analysis of bronchoalveolar lavage (BAL) aspirate
Clinical Study IdentifierNCT02652247
SponsorVanderbilt University Medical Center
Last Modified on24 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 or older
Admitted to the Vanderbilt Trauma (TICU) and Surgical Intensive Care Units (SICU)
Mechanically ventilated for ≥2 successive days (without planned extubation within 24 hours of enrollment)

Exclusion Criteria

Less than 18 years of age
Expected survival less than 24 hours
Anticipated extubation within 24 hours of enrollment
Conditions limiting the subject's ability to tolerate collection of lavage specimens, including: FIO2 > 80%; PEEP > 16 cmH2O; Intracranial pressure >20 cmH2O; Tracheal or mucosal bleeding; Platelet count < 20,000 cells/uL; INR > 2.0
Known prisoners
Pneumonia diagnosis at the time of ICU admission
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