CD22 Targeting CAR-T Therapy Against B Cell Hematological Malignancies

  • STATUS
    Not Recruiting
  • participants needed
    10
  • sponsor
    Kai Lin Xu; Jun Nian Zheng
Updated on 21 January 2021
Investigator
Jiang Cao, M.D., Ph.D.
Primary Contact
Affiliated hospital of Xuzhou medical college (6.1 mi away) Contact

Summary

CD19 expression on B cell frequently lost after CD19-targeting CAR-T therapy. In present study, we construct a CD22-targeting chimeric antigen receptor to overcome this issue.

Description

CD19 is an ideal target with great potential for treating B-cell-derived hematological malignancies. Although the complete remission rate is as high as 93% by using CD19-targeting CAR-T technology, approximately 60% patients will have recurrent disease. Among all the recurrent patients, two thirds is revealed to loss their CD19 expression on B cell surface. For overcoming this issue, we establish a new chimeric antigen receptor containing humanized single chain antibody sequence to target CD22 molecule on B cells.

Details
Condition Recurrent or Refractory B Cell Malignancy
Treatment CD22 CAR-T
Clinical Study IdentifierNCT02794961
SponsorKai Lin Xu; Jun Nian Zheng
Last Modified on21 January 2021

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