Minocycline and Celecoxib as Adjunctive Treatments of Bipolar Depression

    Not Recruiting
  • participants needed
  • sponsor
    Pakistan Institute of Learning and Living
Updated on 23 January 2021
bipolar disorder
depressive disorder
depressive symptoms
major depressive disorder


Bipolar disorder is a leading cause of disability worldwide. A high proportion of patients with bipolar disorder experience persistent depressive symptoms that do not respond to standard drug treatments. Recent evidence has suggested that anti-inflammatory treatment may reduce depressive symptoms. Minocycline is a tetracycline antibiotic with good central nervous system (CNS) penetration that has been suggested to be effective as an adjunct drug in improving depressive symptoms. Celecoxib, a selective cyclooxygenase 2 (COX-2) inhibitor, has also shown promising results in the treatment of depressive symptoms. In this factorial design, double blind, randomised controlled trial the investigators will determine the efficacy of minocycline and/or celecoxib as an adjunct to treatment as usual (TAU) in patients experiencing a depressive phase of bipolar I or II disorder. The investigators hypothesise that augmentation with minocycline and/or celecoxib will lead to an improvement in depressive symptoms in participants in comparison with placebo.

Condition mood disorder, Endogenous depression, Depression, Bipolar Disorder
Treatment Placebo, Celecoxib, Minocycline
Clinical Study IdentifierNCT02703363
SponsorPakistan Institute of Learning and Living
Last Modified on23 January 2021

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