Last updated on June 2014

Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation Radiation Therapy and/or Surgery in Treating Patients With Ewing's Sarcoma


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Sarcoma
  • Age: - 49 Years
  • Gender: Male or Female
  • Other:
    DISEASE CHARACTERISTICS:
    Histologically confirmed tumor of the Ewing's family of bone or soft tissue
    Ewing's sarcoma
    Peripheral primitive neuroectodermal tumor
    Disease meeting one of the following criteria:
    Resectable localized disease (tumor volume less than 200 mL)
    Localized disease previously resected at diagnosis
    Unresectable disease (at least 200 mL tumor volume) but radiotherapy as local
    control can be delayed
    Localized disease with early radiotherapy required
    Pulmonary and/or pleural metastases only
    Extrapulmonary/pleural metastases (skeleton, bone marrow, lymph nodes)
    No more than 45 days since definitive biopsy
    PATIENT CHARACTERISTICS:
    Age:
    Under 50
    Performance status:
    Not specified
    Life expectancy:
    Not specified
    Hematopoietic:
    Not specified
    Hepatic:
    Not specified
    Renal:
    Renal function normal
    Glomerular filtration rate at least 60 mL/min
    Cardiovascular:
    Normal cardiac function
    Fractional shortening at least 29%
    Ejection fraction at least 40%
    Other:
    No medical, psychiatric, or social condition that would preclude study participation
    PRIOR CONCURRENT THERAPY:
    Biologic therapy:
    Not specified
    Chemotherapy:
    No prior chemotherapy
    Endocrine therapy:
    Not specified
    Radiotherapy:
    Not specified
    Surgery:
    See Disease Characteristics
    DISEASE CHARACTERISTICS:
    Histologically confirmed tumor of the Ewing's family of bone or soft tissue
    Ewing's sarcoma
    Peripheral primitive neuroectodermal tumor
    Disease meeting one of the following criteria:
    Resectable localized disease (tumor volume less than 200 mL)
    Localized disease previously resected at diagnosis
    Unresectable disease (at least 200 mL tumor volume) but radiotherapy as local
    control can be delayed
    Localized disease with early radiotherapy required
    Pulmonary and/or pleural metastases only
    Extrapulmonary/pleural metastases (skeleton, bone marrow, lymph nodes)
    No more than 45 days since definitive biopsy
    PATIENT CHARACTERISTICS:
    Age:
    Under 50
    Performance status:
    Not specified
    Life expectancy:
    Not specified
    Hematopoietic:
    Not specified
    Hepatic:
    Not specified
    Renal:
    Renal function normal
    Glomerular filtration rate at least 60 mL/min
    Cardiovascular:
    Normal cardiac function
    Fractional shortening at least 29%
    Ejection fraction at least 40%
    Other:
    No medical, psychiatric, or social condition that would preclude study participation
    PRIOR CONCURRENT THERAPY:
    Biologic therapy:
    Not specified
    Chemotherapy:
    No prior chemotherapy
    Endocrine therapy:
    Not specified
    Radiotherapy:
    Not specified
    Surgery:
    See Disease Characteristics
    DISEASE CHARACTERISTICS:
    Histologically confirmed tumor of the Ewing's family of bone or soft tissue
    Ewing's sarcoma
    Peripheral primitive neuroectodermal tumor
    Disease meeting one of the following criteria:
    Resectable localized disease (tumor volume less than 200 mL)
    Localized disease previously resected at diagnosis
    Unresectable disease (at least 200 mL tumor volume) but radiotherapy as local
    control can be delayed
    Localized disease with early radiotherapy required
    Pulmonary and/or pleural metastases only
    Extrapulmonary/pleural metastases (skeleton, bone marrow, lymph nodes)
    No more than 45 days since definitive biopsy
    PATIENT CHARACTERISTICS:
    Age:
    Under 50
    Performance status:
    Not specified
    Life expectancy:
    Not specified
    Hematopoietic:
    Not specified
    Hepatic:
    Not specified
    Renal:
    Renal function normal
    Glomerular filtration rate at least 60 mL/min
    Cardiovascular:
    Normal cardiac function
    Fractional shortening at least 29%
    Ejection fraction at least 40%
    Other:
    No medical, psychiatric, or social condition that would preclude study participation
    PRIOR CONCURRENT THERAPY:
    Biologic therapy:
    Not specified
    Chemotherapy:
    No prior chemotherapy
    Endocrine therapy:
    Not specified
    Radiotherapy:
    Not specified
    Surgery:
    See Disease Characteristics
    DISEASE CHARACTERISTICS:
    Histologically confirmed tumor of the Ewing's family of bone or soft tissue
    Ewing's sarcoma
    Peripheral primitive neuroectodermal tumor
    Disease meeting one of the following criteria:
    Resectable localized disease (tumor volume less than 200 mL)
    Localized disease previously resected at diagnosis
    Unresectable disease (at least 200 mL tumor volume) but radiotherapy as local
    control can be delayed
    Localized disease with early radiotherapy required
    Pulmonary and/or pleural metastases only
    Extrapulmonary/pleural metastases (skeleton, bone marrow, lymph nodes)
    No more than 45 days since definitive biopsy
    PATIENT CHARACTERISTICS:
    Age:
    Under 50
    Performance status:
    Not specified
    Life expectancy:
    Not specified
    Hematopoietic:
    Not specified
    Hepatic:
    Not specified
    Renal:
    Renal function normal
    Glomerular filtration rate at least 60 mL/min
    Cardiovascular:
    Normal cardiac function
    Fractional shortening at least 29%
    Ejection fraction at least 40%
    Other:
    No medical, psychiatric, or social condition that would preclude study participation
    PRIOR CONCURRENT THERAPY:
    Biologic therapy:
    Not specified
    Chemotherapy:
    No prior chemotherapy
    Endocrine therapy:
    Not specified
    Radiotherapy:
    Not specified
    Surgery:
    See Disease Characteristics
    DISEASE CHARACTERISTICS:
    Histologically confirmed tumor of the Ewing's family of bone or soft tissue
    Ewing's sarcoma
    Peripheral primitive neuroectodermal tumor
    Disease meeting one of the following criteria:
    Resectable localized disease (tumor volume less than 200 mL)
    Localized disease previously resected at diagnosis
    Unresectable disease (at least 200 mL tumor volume) but radiotherapy as local
    control can be delayed
    Localized disease with early radiotherapy required
    Pulmonary and/or pleural metastases only
    Extrapulmonary/pleural metastases (skeleton, bone marrow, lymph nodes)
    No more than 45 days since definitive biopsy
    PATIENT CHARACTERISTICS:
    Age:
    Under 50
    Performance status:
    Not specified
    Life expectancy:
    Not specified
    Hematopoietic:
    Not specified
    Hepatic:
    Not specified
    Renal:
    Renal function normal
    Glomerular filtration rate at least 60 mL/min
    Cardiovascular:
    Normal cardiac function
    Fractional shortening at least 29%
    Ejection fraction at least 40%
    Other:
    No medical, psychiatric, or social condition that would preclude study participation
    PRIOR CONCURRENT THERAPY:
    Biologic therapy:
    Not specified
    Chemotherapy:
    No prior chemotherapy
    Endocrine therapy:
    Not specified
    Radiotherapy:
    Not specified
    Surgery:
    See Disease Characteristics

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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