Digoxin Short Term Treatment Assessment Randomized Trial in AHF

  • End date
    Jan 31, 2040
  • participants needed
  • sponsor
    University of Monastir
Updated on 4 August 2021


AHFS management is challenging and most of the used drugs has failed to decrease post-discharge mortality and readmission rates which represent the most important goal in AHFS.

Digoxin processes many characteristics of a beneficial drug for heart failure, however recent publications has rose concerns about its safety profile and therefore decreasing its use.

Whether digoxin is efficient and safe in short term treatment of acute heart failure is a question that should be studied.


AHFS management is challenging given the heterogeniety of the patient population, absence of a universally accepted definition, incomplete understanding of its pathophysiology, and lack of evidence based guidelines.

The majority of patients appear to respond well to initial therapies consisting of loop diuretics and vasoactive agents. however, this treatments failed to decrease post-discharge mortality and readmission rates which represent the most important goal in AHFS.

In the last few years, many drugs has been tested in AHFS setting trying to adress this issue, however results has been disappointing in term of efficacy and / or safety.

Although evidence supports the beneficial effects of digoxin on hemodynamic, neurohormonal, and electrophysiological parameters in patients with CHF, recent publications has rose concerns about its safety profile and therefore decreasing its use.

The effects of digoxin alone or in combination with other vasodilators are seen within few hours of its administration and result in increased cardiac output, decreased pulmonary wedge pressure, increased ejection fraction, and improved neurohormonal profile without changes in blood pressure.

All this findings made us rose the question of whether digoxin is effective or not in short term treatment of acute heart failure ?

Condition Acute Heart Failure
Treatment Placebo, Digoxin
Clinical Study IdentifierNCT02544815
SponsorUniversity of Monastir
Last Modified on4 August 2021


Yes No Not Sure

Inclusion Criteria

Able to provide informed written consent
Male or female aged 18 years old
Admitted for AHFS
Able to be randomized within 12 hours from presentation to the hospital

Exclusion Criteria

Pregnant or breast feeding women
Known severe or terminal renal failure
Previous hepatic impairment
Major surgery within 30 days
Hematocrit < 25%
Alteration of consciousness GCS < 15
Critically ill patients needing immediate mechanical hemodynamic of ventilatory support
Confirmed or suspected diagnosis of ACS within 45 days before inclusion
Severe arrhythmias including significant sinoatrial or atrioventricular blocks or WPW syndrome
Implantable cardiac devices including pacemakers and defibrillators
Hypertrophic obstructive, restrictive, or constrictive cardiomyopathy
Noncardiac pulmonary edema, including suspected sepsis
Administration of an investigational drug or implantation of an investigational device or participation in another trial within 30 days before screening
Previous treatment with digoxin within 15 days before inclusion or contra-indications to digoxin
Inability to follow instructions or comply with follow-up procedures
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note