N-acetylcysteine for the Treatment of Cannabis Dependence: Working Mechanisms

  • STATUS
    Recruiting
  • End date
    Feb 1, 2023
  • participants needed
    75
  • sponsor
    Universitair Ziekenhuis Brussel
Updated on 23 February 2022
n-acetylcysteine
Accepts healthy volunteers

Summary

This study investigates the effects of repeated NAC administration on glutamate concentrations in the anterior cingulate cortex (ACC), on neurocognitive functioning, and on neuro-inflammatory parameters in adult cannabis-dependent individuals.

Details
Condition Cannabis Use Disorder, Cannabis Dependence
Treatment magnetic resonance imaging, N-acetylcysteine, Placebo Oral Tablet, Neurocognitive measures, Neuro-inflammatory measures
Clinical Study IdentifierNCT03221231
SponsorUniversitair Ziekenhuis Brussel
Last Modified on23 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Current DSM-IV diagnosis of cannabis dependence, >1 week detoxified and abstinent
Able to provide written informed consent and to comply with study procedures
Dutch speaking (Dutch as primary language)

Exclusion Criteria

Currently dependent on any substance other than cannabis, alcohol or nicotine
History of any major internal disease (including diabetes, cardiovascular disease, lung disease, liver or kidney disease)
An active or any history of neurological disorder, including but not limited to seizure disorder, epilepsy, stroke, neurological disease, cognitive impairment, head trauma with prolonged loss of consciousness (>10 minutes), or migraine headaches
An active or a history of a psychiatric disorder including, but not limited to, depression, schizophrenia, bipolar disorder, anxiety, or other psychiatric disorders
Asthma
Known hypersensitivity or allergy to n-acetylcysteine, or receiving chronic therapy with medication that could interact adversely with n-acetylcysteine within 30 days prior to randomization (i.e., nitroglycerin, ACE inhibitors or antihypertensive drugs, anti-coagulants)
Exclusion criteria for MRI: having metal in the body and/or having claustrophobia
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

0/250

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note