N-acetylcysteine for the Treatment of Cannabis Dependence: Working Mechanisms

  • End date
    Feb 1, 2023
  • participants needed
  • sponsor
    Universitair Ziekenhuis Brussel
Updated on 23 February 2022
Accepts healthy volunteers


This study investigates the effects of repeated NAC administration on glutamate concentrations in the anterior cingulate cortex (ACC), on neurocognitive functioning, and on neuro-inflammatory parameters in adult cannabis-dependent individuals.

Condition Cannabis Use Disorder, Cannabis Dependence
Treatment magnetic resonance imaging, N-acetylcysteine, Placebo Oral Tablet, Neurocognitive measures, Neuro-inflammatory measures
Clinical Study IdentifierNCT03221231
SponsorUniversitair Ziekenhuis Brussel
Last Modified on23 February 2022


Yes No Not Sure

Inclusion Criteria

Current DSM-IV diagnosis of cannabis dependence, >1 week detoxified and abstinent
Able to provide written informed consent and to comply with study procedures
Dutch speaking (Dutch as primary language)

Exclusion Criteria

Currently dependent on any substance other than cannabis, alcohol or nicotine
History of any major internal disease (including diabetes, cardiovascular disease, lung disease, liver or kidney disease)
An active or any history of neurological disorder, including but not limited to seizure disorder, epilepsy, stroke, neurological disease, cognitive impairment, head trauma with prolonged loss of consciousness (>10 minutes), or migraine headaches
An active or a history of a psychiatric disorder including, but not limited to, depression, schizophrenia, bipolar disorder, anxiety, or other psychiatric disorders
Known hypersensitivity or allergy to n-acetylcysteine, or receiving chronic therapy with medication that could interact adversely with n-acetylcysteine within 30 days prior to randomization (i.e., nitroglycerin, ACE inhibitors or antihypertensive drugs, anti-coagulants)
Exclusion criteria for MRI: having metal in the body and/or having claustrophobia
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