A Phase II Study of the FIL on Elderly Frail Patients With DLBCL

    Not Recruiting
  • participants needed
  • sponsor
    Fondazione Italiana Linfomi ONLUS
Updated on 4 August 2021
Marina Cesaretti
Primary Contact
Azienda Ospedaliera Arcispedale Santa Maria Nuova - IRCCS - Ematologia (0.0 mi away) Contact
+31 other location


A phase II study to evaluate the combination of Lenalidomide and Rituximab as front line therapy for the treatment of elderly frail patients evaluated in CGA with Diffuse Large B-cells non-Hodgkin Lymphoma.


This is a prospective, multicenter, single arm, phase II trial in elderly patients ( 70 years) affected by DLBCL defined as frail according to CGA and previously untreated.

The primary endpoint is to evaluate the efficacy of the R2 (Revlimid+Rituximab) combination in first line DLBCL patients not candidate for the standard R-CHOP (or R-CHOP like) treatments due to the frail status.

Condition Diffuse Large B-cells Non-Hodgkin Lymphoma, Diffuse Large B-cells Non-Hodgkin Lymphoma, Diffuse Large B-cells Non-Hodgkin Lymphoma, Diffuse Large B-cells Non-Hodgkin Lymphoma
Treatment Rituximab-Dexamethasone-Lenalidomide
Clinical Study IdentifierNCT02955823
SponsorFondazione Italiana Linfomi ONLUS
Last Modified on4 August 2021

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