Last updated on February 2018

Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients


Brief description of study

To validate blood draws via a central venous catheter (Port A Cath ) for pharmacokinetic studies of ciprofloxacin in patients under treatment for childhood cancer.

Detailed Study Description

The concentration of cipro will be determined using a validated high-performance liquid chromatographic (HPLC) method with fluorescence detection. Unbound concentration will be determined by adjusting the pH of the plasma samples to physiological pH (7.4) in a CO2 incubator, followed by ultrafiltration and extraction of ciprofloxacin from the ultrafiltrate (as described above) prior to injection onto the HPLC system.

Clinical Study Identifier: NCT02967341

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Recruitment Status: Open


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