Efficacy of RIVAstigmine on Motor, Cognitive and Behavioural Impairment in Progressive Supranuclear Palsy (RIVA-PSP)

  • STATUS
    Recruiting
  • End date
    Jul 31, 2023
  • participants needed
    106
  • sponsor
    Assistance Publique Hopitaux De Marseille
Updated on 9 August 2022
screening procedures
mini-mental state examination
parkinson's disease
donepezil
parkinsonism
gaze palsy
dopa

Summary

Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease from the parkinsonian syndrome group. It represents 5 to 10% of all parkinsonian syndromes and affects 3,000 to 10,000 persons in France. PSP is characterised by a doparesistant parkinsonism with axial signs such as early gait instability and falls, oculomotor signs such as a vertical gaze palsy, dysphagia and dysarthria, and both cognitive and behavioural disturbances. The latter predominantly manifest as psycho-motor slowness, apathy and frontal executive deficits. Swallowing impairments and falls may lead to life-threatening situations and death occurs 6-9 years after disease onset.

Apart from L-dopa which may transiently and inconsistently improve motor symptoms no effective symptomatic, disease-modifying or neuroprotective therapy is presently available to reduce disability in any way. Therefore these patients often receive mostly non-medical care such as physiotherapy and speech therapy.

In addition to dopaminergic degeneration there is evidence of cholinergic deficits in PSP correlated with gait and balance impairments . This stands in contrast with the limited number of studies of cholinergic augmentation strategies in PSP.

Trials of cholinesterase inhibitors in PSP have produced rather conflicting results: donepezil improves cognition but deteriorates some motor functions whereas a case series of 5 PSP patients treated with rivastigmine found an improvement in several cognitive aspects and no deterioration of motor functions .On the other hand in Parkinson's disease there is convincing evidence of a positive effect of rivastigmine on cognition , apathy and falls Investigators' hypothesis is that rivastigmine (an acetyl- and butyryl-cholinesterase inhibitor) may reduce gait and postural impairment in PSP and may therefore limit the number of falls and their consequences both in terms of injuries sustained (fractures etc...) and on the patients' autonomy. In addition investigators hypothesise that rivastigmine may also reduce the cognitive and behavioural impairment associated with PSP. Taken together these improvements are likely to produce a significant effect on the patients' quality of life and their caregiver burden.

Details
Condition Progressive Supranuclear Palsy (PSP)
Treatment Placebo, rivastigmine
Clinical Study IdentifierNCT02839642
SponsorAssistance Publique Hopitaux De Marseille
Last Modified on9 August 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Probable PSP of the Richardson subtype as defined by the NINDS-SPSP criteria modified so as to allow inclusions of patients who have first fallen within 3 years of disease onset
Aged 41 to 80 years at the time of screening
Judged by site investigator to be able to comply with gait/balance and neuropsychological evaluations at baseline and throughout the study
Able to ambulate independently or with assistance (cane)
Score ≥ 20 on the mini-mental state examination (MMSE) at screening
A reliable caregiver - defined as a person having frequent contact with subject (≥ 3 hours per day) and willing to fill the fall diaries and monitor study medication compliance and the subject's health and concomitant medication throughout the study - must accompany the subject to all visits
A fall or near fall rate ≥ 2/week in average (estimated through interview at screening and confirmed during a 2-week period between screening and baseline using fall postcards)
Any parkinsonian medication taken by the subject must be stable in dose for 4 weeks prior to screening and must remain stable for the duration of the study
Stable on all other chronic medications for 4 weeks prior to screening
Written informed consent provided by subject and caregiver

Exclusion Criteria

Non ambulatory patient
History and clinical examination suggesting another parkinsonian syndrome (Parkinson's disease, Dementia with Lewy Bodies, Corticobasal Degeneration, Multisystem Atrophy, Vascular Parkinsonism, tumoral parkinsonism, anti-psychotic drug-induced parkinsonism)
Presence of other significant neurological or psychiatric disorders: Alzheimer's disease, epilepsy, history of stroke, psychotic disorder, severe bipolar or unipolar disorder
A fall or near fall rate < 2/week in average (during a 2-week period between screening and baseline using fall postcards)
Insufficient fluency in local language to complete neuropsychological, global and gait/balance assessments
Score < 20 on the mini-mental state examination at screening
Within 4 weeks of screening or during the course of the study concurrent treatment with any cholinesterase inhibitor medication (donepezil, galantamine, rivastigmine) or any cholinergic agent (agonist or antagonist) including memantine
History of deep brain stimulation surgery
Within 4 weeks of screening or during the course of the study concurrent treatment with beta blockers, any antipsychotic drugs or mood stabilisers
Any malignancy within 5 years of screening or current significant - judged as such by the site investigator - hematological, endocrine, cardiovascular, renal, hepatic, gastrointestinal, or neurological disease
Presence of an active gastro-duodenal ulcer, unstable asthma or chronic obstructive pulmonary disease
History of or current urinary retention requiring either anticholinergic medication or urethral catheterisation
The systolic blood pressure measurement is > 190 or < 85 mm Hg and/or the diastolic blood pressure measurement is > 105 or < 50 mm Hg at screening
Clinically significant laboratory abnormalities at screening, including creatinine ≥ 2.5 mg/dL, alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥ 3 times the upper limit of the normal reference range
The ECG is abnormal at screening and judged to be clinically significant by the site investigator. Particular attention will be given to any sign suggesting conduction disorders
Treatment with any investigational drugs or device within 60 days of screening
Ongoing pregnancy or lactation. Women with childbearing potential not using any form of efficacious contraception
Any contraindication for rivastigmine as defined by the ANSM
Known hypersensitivity to rivastigmine or any cholinesterase inhibitor medication
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