Pathogenesis of Non-alcoholic Steatohepatitis and Liver Regeneration After Bariatric Surgery (NALKOSTEP)

  • STATUS
    Recruiting
  • participants needed
    200
  • sponsor
    RWTH Aachen University
Updated on 28 January 2023
gastrectomy
fatty liver
fibroscan
bariatric surgery
gastric bypass
roux-en-y
obesity surgery

Summary

Obesity and obesity related health problems are globally recognized as one of the major threats to public health. Bariatric surgery is the most effective and durable therapy option for obesity and the improvement of obesity related co-morbidities. "Non alcoholic steatohepatitis" (NASH) is an important comorbidity of obesity and improves after surgical intervention. In this study investigators try to enlighten the weight independent mechanism for the effects of bariatric surgery. Patients who are assigned to a bariatric procedure will be observed for at least 24 month. A liver and adipose tissue samples are gained during the operation. Liver function and morphology are observed before and after operation with LiMAx, FibroScan and ultrasound. Systemic inflammation is measured in blood samples before and after surgical intervention. In order to check the microbiome stool samples are collected throughout the entire observation period.

Description

Every patient who is scheduled for bariatric surgery in the university hospital Aachen will be evaluated for this study. After informed consent baseline measurements are performed preoperative. Baseline measurements involve blood and stool samples, LiMAx, FibroScan and ultrasound. During the operation a liver, a subcutaneous and visceral fat sample are taken to analyse liver histology and inflammation as well as fatty tissue signaling. After the operation patients are observed 24 month. Further blood samples are taken on the first postoperative day, 2 and 4 weeks, 3, 6, 12, 18 and 24 month after the operation. Stool samples are taken 2 and 4 weeks, 3, 6, 12, 18 and 24 month after the intervention. The LiMAx test, a test analysing the liver function, is performed 4 weeks, 6, 12 and 24 month after the operation. The morphologic liver structure is evaluated by FibroScan and ultrasound 4 weeks, 6, 12 and 24 month postoperative.

Details
Condition Bariatric Surgery Candidate, Nonalcoholic Steatohepatitis, Obesity
Treatment Sleeve-Gastrectomy, Roux en Y gastric bypass
Clinical Study IdentifierNCT02792634
SponsorRWTH Aachen University
Last Modified on28 January 2023

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