Proton Radiation for Unresectable Borderline Resectable or Medically Inoperable Carcinoma of the Pancreas
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- STATUS
- Recruiting
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- End date
- Oct 23, 2040
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- participants needed
- 60
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- sponsor
- Proton Collaborative Group
Summary
The prognosis for patients with localized pancreatic adenocarcinoma who are not surgical candidates is poor. Patients characterized as having "borderline resectable" disease treated with preoperative chemo-radiotherapy fair somewhat better - although many of these patients are not converted to resectability. It may be argued that intensification of local and regional therapy might 1.) Increase the share of patients able to undergo curative surgery and 2.) Improve the local disease control interval and extend survival for patients who remain unresectable. Therefore, the purpose of this research study is to determine if an increase in the number of surgical resection pancreatic adenocarcinoma is higher than historical data by using a combined treatment of proton radiation with capecitabine (oral chemotherapy).
Description
Participants as part of this research study will receive Proton radiation over 6 weeks with oral chemotherapy (capecitabine) only taken on radiation days.
In addition, If surgery is an option, then surgical resection will be performed at least 8 weeks after treatment with radiation and chemotherapy.
Quality of Life questionnaires are a part of this study.The Fact-Hep questionnaires will be filled out by the participant at strategic time points in the treatment course.
Details
| Condition | Pancreatic Cancer, Pancreatic disorder, Neoplasm of unspecified nature of digestive system, Pancreatic Disorders, Islet Ce417ll Cancer, Digestive System Neoplasms, cancer of the pancreas, pancreatic cancers, cancer, pancreatic |
|---|---|
| Treatment | Capecitabine, Surgical Resection, Proton Radiation, FACT-Hep questionnaire |
| Clinical Study Identifier | NCT02598349 |
| Sponsor | Proton Collaborative Group |
| Last Modified on | 23 January 2021 |
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