Air Pollution Study: The Effect of Ozone on the Lung

  • End date
    Dec 25, 2022
  • participants needed
  • sponsor
    Rutgers, The State University of New Jersey
Updated on 23 February 2022
Accepts healthy volunteers


The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.


Subjects will be asked to come to the Rutgers EOHSI clinical center (Piscataway, NJ) for 5 study visits. A physical exam to determine eligibility will be done at the first study visit. If the subject is healthy and able to produce a sputum sample, he/she will then be scheduled for 2 3-hour exposure visits. One exposure will be to clean air and the other exposure will be to 0.2 ppm ozone. During the exposures, subjects will be requested to ride an exercise bicycle intermittently (approximately every 15 minutes). A follow-up visit for sputum collection will be scheduled either 24, 48, or 72 hours after each exposure visit. Blood, urine, and exhaled breath samples will also be collected at each visit.

Condition Air Pollution
Treatment Clean Air, Ozone, Ozone
Clinical Study IdentifierNCT02673775
SponsorRutgers, The State University of New Jersey
Last Modified on23 February 2022


Yes No Not Sure

Inclusion Criteria

Healthy men and women

Exclusion Criteria

Cardiovascular disease
Respiratory disease
HIV infection
History of smoking within the last 5 years
Daily use of antioxidant supplements (e.g., Vitamin C/E, selenium, beta-carotene, lycopene, lutein, zeaxanthin, or ginkgo biloba)
Orthopedic or rheumatological conditions that would interfere with cycle use
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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