Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material

  • days left to enroll
  • participants needed
  • sponsor
    University of California, Los Angeles
Updated on 26 January 2021
root canal therapy
root canal filling


Non-surgical root canal therapy (RCT) represents a standard of treatment that addresses infected pulp tissue in teeth and protects against future infection while preserving the tooth for the patient for mainly cosmetic purposes. RCT is offered as the better cosmetic, cheaper, and less time intensive treatment option for a patient compared to those of dental implantation. Dental implantation is the alternative to RCT, and they are both originally offered at the time of the initial consultation. RCT involves non-surgically removing dental pulp comprising blood vessels and nerve tissue, decontaminating residually infected tissue, and using a filler material to replace the non-surgically created space where the pulp was removed. Currently, standard of care treatment for RCT utilizes gutta-percha as the root canal filling material. Our research group has previously demonstrated NDGP's improvement in tensile strength compared to those of gutta-percha. This research studies a new type of filler, gutta-percha modified by the addition of nanodiamond material (NDGP). This is an equivalence study of NDGP and standard gutta-percha administration.

Condition Pulp Necrosis, Dental pulp disorder, Nerve Root Pain Nec, endodontic disease
Treatment Nanodiamond reinforced Gutta Percha, Gutta Percha, Gutta Percha
Clinical Study IdentifierNCT02698163
SponsorUniversity of California, Los Angeles
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

years old or older when patient is referred to UCLA endodontics department for root canal therapy
Patient referral to UCLA endodontics department for root canal therapy

Exclusion Criteria

preoperative periodontal disease
prior non-surgical and surgical endodontic treatment
currently taking medications used to treat osteoporosis or any form of IV biphosphonates
allergic to dental materials
dental phobia
MD consult/medically compromised/prophylaxis needed
developmental/congenital disorders
craniofacial disorder/syndromic cases
low pain tolerance ascertained from past dental experience
current moderate to severe periodontitis
previous RCT/initiated pulp therapy
previous apical surgery
previous surgical root canal procedure
with psychiatric and/or mental health history
poor oral hygiene
poor diet
illicit and/or recreational drug use
complicated dental history
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note