Axitinib in Metastatic Renal Cell Carcinoma Patients With Favorable Prognostic Factors

  • STATUS
    Not Recruiting
  • participants needed
    21
  • sponsor
    Kidney Cancer Research Bureau
Updated on 23 January 2021
sunitinib
measurable disease
carcinoma
axitinib
pazopanib
metastatic renal cell carcinoma

Summary

Aim of the FavorAx study is to evaluate preliminary efficacy and safety of Axitinib in metastatic renal cell carcinoma patients with favorable IMDC prognostic factors who had progressed on sunitinib or pazopanib in the first-line setting.

Description

Axitinib is a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, platelet-derived growth factor receptor-, and c-kit. The trial of comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS) was an international randomized Phase III study designed for registration purposes. This trial randomized 723 metastatic renal cell carcinoma patients with any prognostic features to axitinib or sorafenib in the second-line setting and demonstrated significant clinical benefit of axitinib.

Aim of present FavorAx study is to evaluate preliminary efficacy and safety of Axitinib in metastatic renal cell carcinoma patients with favorable IMDC prognostic factors who had progressed on sunitinib or pazopanib in the first-line setting.

Details
Condition Renal Cell Carcinoma
Treatment Axitinib
Clinical Study IdentifierNCT02700568
SponsorKidney Cancer Research Bureau
Last Modified on23 January 2021

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