The Role of Minerelocorticoid Receptor on Modulating Aldosterone Production

    Not Recruiting
  • participants needed
  • sponsor
    Brigham and Women's Hospital
Updated on 13 June 2021
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The purpose of this research protocol is to determine if the same effects are observed in vivo in humans using a similar approach. Demonstrating that mineralocorticoid acts on zona glomerulosa cells to regulate aldosterone production in a short feedback loop would provide important insight into hormone regulation, and explain variability in pathophysiologic states such as hypertension and cardiovascular diseases.


In order to provide additional evidence indicating the presence of functional and in order to provide additional evidence indicating the presence of functional mineralocorticoid receptors (MR) on zona glomerulosa (ZG) cells, the investigators propose the following protocol in healthy volunteers. The investigators will evaluate aldosterone and cortisol production in response to an angiotensin II infusion after three separate test conditions: 1) placebo, 2) following a single dose of fludrocortisone, and 3) following a single dose of eplerenone (a MR antagonist).

Condition Healthy Volunteers
Treatment Placebo, Eplerenone, Fludrocortisone
Clinical Study IdentifierNCT02871648
SponsorBrigham and Women's Hospital
Last Modified on13 June 2021

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