Physical Exercise Augmented CBT for GAD (PEXACOG)

  • End date
    Dec 11, 2023
  • participants needed
  • sponsor
    Solli Distriktspsykiatriske Senter
Updated on 11 May 2022
behavior therapy
cognitive therapy
anxiety disorder


Generalised anxiety disorder (GAD) is a severe and debilitating anxiety disorder that is highly prevalent among older adults. Anxiety and GAD is a well-documented risk factor for the development of other severe conditions such as depression and dementia, and effective treatments are called for. However, recommended treatment for GAD has consistently been found to yield blunted response rates for older adults compared to younger patients.

The purpose of this study is to evaluate the effects of exercise-augmented cognitive behaviour therapy for older adults with GAD. Exercise augmented CBT is expected to yield better results than standard CBT in terms of greater reduction of symptoms and increased rates of remission. The investigators will also investigate the effects of treatment on biological, physiological and neuropsychological measures.

Condition Generalized Anxiety Disorder
Treatment physical exercise, Cognitive Behavioural Therapy, Placebo control
Clinical Study IdentifierNCT02690441
SponsorSolli Distriktspsykiatriske Senter
Last Modified on11 May 2022


Yes No Not Sure

Inclusion Criteria

Primary diagnosis of GAD

Exclusion Criteria

Substance abuse
Use of benzodiazepines, use of antipsychotica
Lack of ability to stabilize other psychotropic medication during participating in the study
Medical condition that precludes participation in physical exercise
Severe major depression as determined by the MINI International Neuropsychiatric Interview
Life-time history of psychosis and/or mania
Participation in other ongoing psychotherapy
Organic brain disease
Positive screening for dementia with Mini Mental State Examination
Currently engaged in a regular physical exercise program
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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