Biological Collection and Registry of Patients Who Will Have a TAVR (Transcatheter Aortic Valve Replacement) Intervention

  • End date
    Dec 22, 2022
  • participants needed
  • sponsor
    Action, France
Updated on 22 January 2021
aortic valve replacement


A sample of plasma and whole blood will be obtained at 4 time points (pre-procedural, early post-procedural, at hospital discharge and during an eventual visite at 3 or 6 months post-procedural). Test for platelet reactivity (LTA, light transmittance aggregometry and Elisa PRI, Platelet reactivity index), multimeric VWF (von Willebrand factor) and blood level of NET: neutrophil extracellular traps(flow cytometry and ELISA) analyses will be performed at the time of blood sampling. Aliquots of plasma will be stored and frozen for further analyses


There are two major objectives:

  • To correlate changes in VWF, platelet reactivity and blood level of NET after TAVR with clinical outcomes
  • To correlate changes in VWF, platelet reactivity and blood level of NET with antithrombotic regimens after TAVR (direct anticoagulants apixaban versus standard of care, ie Vitamin K antagonist or antiplatelet therapy).

Condition Transcatheter Aortic Valve Implantation, Transcatheter Aortic Valve Replacement, TAVI, transcatheter aortic valve implant
Clinical Study IdentifierNCT02812953
SponsorAction, France
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

patient undergoing TAVR intervention
agreement given

Exclusion Criteria

severe thrombopenia ( <40.10^9/L)
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