Chidamide Combined With VDDT Regimen in the Relapse and Refractory Diffuse Large B Cell Lymphoma
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- STATUS
- Recruiting
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- days left to enroll
- 81
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- participants needed
- 20
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- sponsor
- Henan Cancer Hospital
Summary
This is a prospective phase II clinical trial to observe the efficacy and safety of Chidamide combined with VDDT(vinorelbineliposomal doxorubicindexamethasone and thalidomide) in relapsed and refractory patients with diffuse large B-cell lymphoma(DLBCL).
Description
There are one third of diffuse large B-cell Lymphoma patients suffering relapse and refractory, which are the major cause of death among these patients. Vinorelbineliposomal doxorubicinmitoxantrone, dexamethasone and thalidomide have been used in the therapy of patients who failed with Second-line treatments in our center. This regimen is well tolerated but the effect needs to be improved. Chidamidea histone deacetylase inhibitor has been approved for the treatment of refractory T-cell lymphoma in China. The goal is to assess the efficacy and safety of chidamide combined with VDDTvinorelbineliposomal doxorubicindexamethasone and thalidomide in relapse and refractory patients with diffuse large B-cell Lymphoma.
Details
| Condition | Diffuse Large B-Cell Lymphoma, diffuse large cell lymphoma, diffuse large b cell lymphoma |
|---|---|
| Treatment | Dexamethasone, Vinorelbine, thalidomide, Chidamide, Liposomal Doxorubicin or mitoxantrone |
| Clinical Study Identifier | NCT02733380 |
| Sponsor | Henan Cancer Hospital |
| Last Modified on | 24 January 2021 |
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