Last updated on April 2018

EVRIOS : Comparative Evaluation of Low Versus High Doses of Rifampicin


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Osteoarticular Infection
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Adult patients (over 18 years old) who gave their signed inform consent,
  • Who present an osteo-articular infection with susceptible Staphylococcus spp.,
  • To whom a rifampicin based regimen is prescribed, in association with another antibiotic, for at least 14 days,
  • Patients covered by Health Insurance.

Exclusion Criteria:

  • Patients weighing less than 45 kg or more than 150 kg,
  • Patients with active TB (whatever its localization),
  • Presence or anticipated need during the study period, of drugs contraindicated with rifampicin: anticalcineurins, protease inhibitors and nevirapine,
  • Patients with a known and documented rifampicin allergy.
  • Pregnant or breastfeeding woman,
  • Adults legally protected (under judicial protection, guardianship or supervision), persons deprived of their liberty,
  • Patients participating in another interventional clinical trial (biomedical trial or standard care clinical trial).

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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