Last updated on February 2019

Expression of Ku70/XRCC6 in Waldenstr m's Macroglobulinemia

Brief description of study

Waldenstrm's macroglobulinemia is a rare disease whose pathophysiology remains at present poorly understood, although a recurrent mutation (L265P MYD88) has recently been described. Unlike other lymphoproliferative disorders, there is a defect in isotype switching, mechanism involving AID and NHEJ complex. Using a two-dimensional electrophoresis technology, our group showed that MW had a specific proteomic profile, and one of the differentially expressed proteins is Ku70 (encoded by XRCC6 belonging to NHEJ complex) .

The investigators purpose to explore the mechanisms of underexpression of Ku70/XRCC6 (genetic or epigenetic modification) in comparison with other lymphoid malignancies and normal B cells.

Clinical Study Identifier: NCT02640287

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CHRU Nancy

Vandoeuvre les Nancy, France
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Recruitment Status: Open

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