Magnetic Resonance Whole Body Diffusion-Weighted Imaging in Finding Bone or Lymph Node Metastasis in Participants With High-Risk Prostate Cancer

  • End date
    Apr 30, 2026
  • participants needed
  • sponsor
    M.D. Anderson Cancer Center
Updated on 27 January 2022
ct scan
bone scan
prostate specific antigen


This trial studies how well magnetic resonance whole body diffusion-weighted imaging works in finding cancer that has spread to the bone or lymph nodes (metastasis) in participants with high-risk prostate cancer. Diagnostic procedures, such as magnetic resonance whole body diffusion-weighted imaging (a method to show how water moves in a certain area) may help find bone or lymph nodes metastasis.



I. To compare accuracies of whole body magnetic resonance imaging (MRI) versus bone scan plus computed tomography (CT) scan in detecting bone or lymph node metastasis in high risk prostate cancer patients.


Participants undergo standard of care bone scan, CT of the abdomen and pelvis, and pelvic MRI. Participants also undergo magnetic resonance whole body (WB)-diffusion-weighted imaging (DWI) over 20-30 minutes.

Condition Prostate Carcinoma
Treatment computed tomography, magnetic resonance imaging, Whole Body Magnetic Resonance Imaging (MRI), Bone scan, Computed Tomography (CT), Standard of Care Pelvic MRI, Magnetic Resonance Whole Body Diffusion-Weighted Imaging
Clinical Study IdentifierNCT03085043
SponsorM.D. Anderson Cancer Center
Last Modified on27 January 2022


Yes No Not Sure

Inclusion Criteria

Prostate carcinoma patients at high risk for metastasis with prostate-specific antigen (PSA) more than 20 ng/ml and/or Gleason score = 8/ > 8\
Ability to understand and sign informed consent

Exclusion Criteria

Patient is at low risk for metastasis with Gleason score at diagnosis < 8\
Currently receiving or history of systemic therapy with testosterone suppressing medication (i.e., lupron, degarelix, abiraterone, enzalutamide) or local radiation therapy
Contraindication to magnetic resonance imaging (MRI)
Clear my responses

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