Last updated on February 2018

Ticagrelor Versus Clopidogrel in Left Ventricular Remodeling After ST-segment Elevation Myocardial Infarction

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: ST Elevation Myocardial Infarction
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • 18 years and older.
  • First-time onset STEMI patients uneventfully treated with primary PCI within 12 hours of onset of symptom.
  • Infarct-related artery with TIMI 0, 1, or 2 grade flow at the time of initial diagnostic angiography (before wire passage).
  • proximal or mid-portion lesion of epicardial coronary artery.

Exclusion Criteria:

  • Previous history of myocardial infarction.
  • Left bundle branch block on ECG at the time of screening.
  • Cardiogenic shock at the time of randomization.
  • Refractory ventricular arrhythmias or atrial fibrillation.
  • New York Heart Association class IV congestive heart failure.
  • Severe or malignant hypertension (SBP> 180 and/or DBP> 120 mmHg).
  • Fibrinolytic therapy.
  • History of hemorrhagic stroke.
  • Intracranial neoplasm, arteriovenous malformation, or aneurysm.
  • Ischemic stroke within 3 months prior to screening.
  • Platelet count < 100,000/mm3 or hemoglobin < 10 g/dL.
  • A need for oral anticoagulation therapy that cannot be safely discontinued for the duration of the study.
  • Women who are known to be pregnant, have given birth within the past 90 days, or are breast-feeding.
  • Unable to cooperate with protocol requirements and follow-up procedures.
  • A history of P2Y12 receptor inhibitor pretreatment (at least prior 1 month).
  • An increased risk of bradycardia.
  • Concomitant therapy with a strong cytochrome P-450 3A inhibitor or inducer.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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