Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas

  • STATUS
    Recruiting
  • End date
    May 12, 2026
  • participants needed
    60
  • sponsor
    St. Olavs Hospital
Updated on 12 September 2021
adenoma
cabergoline
dopamine agonists
prolactin
hypopituitarism
pituitary adenoma
pituitary disorders
non-functioning pituitary adenoma

Summary

Due to lack of hormone overproduction in non-functioning pituitary adenomas (NFPAs), only the symptomatic adenomas or large adenomas with proven growth and risk for symptoms in near future will undergo pituitary surgery. The remaining adenomas are monitored regularly. Operation of these large adenomas will rarely remove all tumour tissue, and there is also a risk of worsening of pituitary function. Often, adenomas with the highest growth potential are operated several times and some also need radiation therapy, providing additional risk for pituitary failure. Unlike some of the hormone-producing adenomas, there is no established pharmacological treatment for NFPAs. However, there are a few non-randomized studies suggesting that treatment with dopamine agonists may slow growth, and also induce tumour shrinkage. At present, cabergoline is the dopamine agonist most widely used in the treatment of pituitary adenomas secreting prolactin.

Aim is to study the effect of medical treatment with cabergoline in non-functioning pituitary adenomas on the change in tumour volume.

Details
Condition Pituitary Disease, Pituitary Adenoma, Pituitary Disorders, Adenoma, pituitary tumor
Treatment Cabergoline
Clinical Study IdentifierNCT02288962
SponsorSt. Olavs Hospital
Last Modified on12 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

A previously untreated non-functioning pituitary macroadenoma (largest diameter 10 mm) with either demonstrated growth on repeated MRI scans or 2 mm distance to chiasma opticum, or
a residual non-functioning pituitary adenoma after surgery (largest diameter 5 mm) that is either extrasellar and/or with documented growth after surgical treatment of a non-functioning pituitary macroadenoma

Exclusion Criteria

Clear indication for surgery at the time of inclusion
Previous radiation therapy
Pituitary surgery the last 6 months
Previous apoplexy/bleeding in the adenoma
Pregnancy or lactation
Contraindications for cabergoline treatment (Known cardiac valvular disease, known pulmonal, pericardial or retroperitoneal fibrosis, clinical significant liver insufficiency, use of medications that interact with cabergoline
unfit to participate due to any other reason
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