Sequential Analysis in Patients With an Hemopathy

  • STATUS
    Recruiting
  • End date
    Jan 21, 2026
  • participants needed
    246
  • sponsor
    Gustave Roussy, Cancer Campus, Grand Paris
Updated on 21 January 2021

Summary

Recent advances in hematology clearly illustrate that the simple "clonal" nature of various hematological malignancies may not really reflect the reality of malignant cells natural expansion. This has been nicely illustrated in recent works in AML for example where subclones coexists in the same patient at the same time, but could also differentially expand over time because of effects of therapeutics intervention, but also by oncogenic spontaneous events (1).

These observations have been done recently because of next generation sequencing that allows to discriminate in the same tumor samples, different subclones and to analyse the clonal architecture. Sequential analyses could help us to identify the first oncogenic event and to correlate disease progression to the emergence of subclones.

For all these reasons it is of a major interest to precisely understand the architecture of the clone in MPNs, especially to understand which is the initiating event and how from this initial event the clone develops.

In MPNs in which JAK2V617F is the initiating event, its targeting is expected to be extremely effective. If JAK2V617F is a secondary event its targeting might allow to alleviate the MPN, but may favor the development of other malignant hemopathies.

Details
Condition Hemopathy
Treatment blood samples
Clinical Study IdentifierNCT02260739
SponsorGustave Roussy, Cancer Campus, Grand Paris
Last Modified on21 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with a malignant hematological disease
Signed written informed consent
Age and Sex : men and women aged 18 years or older
Patients affiliated to a social security system

Exclusion Criteria

Patients protected by law, in accordance with Articles L1121-L1121-5 to 8 of the Code of Public Health
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