Hemoglobin Neutrophil to Lymphocyte Ratio and Platelet Count Improve Prognosis Prediction in Nasopharyngeal Carcinoma

  • End date
    Dec 22, 2024
  • participants needed
  • sponsor
    Sun Yat-sen University
Updated on 22 January 2021
platelet count
nasopharyngeal carcinoma



  1. In patients with nasopharyngeal carcinoma, there is sometimes a discrepancy between actual clinical outcome and TNM stages because it is an anatomy-based system in which functional factors are not concerned.
  2. Hemoglobin, neutrophil to lymphocyte ratio and platelet count were proved to improve prognosis prediction of TNM staging system in our previous retrospective study.

PURPOSE To validate that the prognostic index based on complete blood count and TNM system had higher prediction efficiency on survival in nasopharyngeal carcinoma than TNM system alone.


Totally 720 patients with non-metastatic nasopharyngeal carcinoma will be include and will be divided into 3 groups (Low Risk, Intermediate Risk and High Risk Groups) according to their prognostic index, which is on basis of blood cell count indexes and TNM stage. The 3 groups of patients will undergo a radical radiotherapy or chemoradiotherapy and be followed until death or the end of the study. Comparison on survivals of the 3 groups will be made to validate the accuracy of the prognostic index. And comparison on prediction efficacy between prognostic index and TNM staging system will be made.

Condition CBC, Prognosis, Cancer Staging, Nasopharyngeal Cancer, Nasopharyngeal Cancer, nasopharyngeal neoplasms, blood count, blood cell counts, blood cell count, cancer stage, complete blood count, full blood count, complete blood count (cbc)
Clinical Study IdentifierNCT02211677
SponsorSun Yat-sen University
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

Nasopharyngeal cancer patients diagnosed by pathology or cytology
UICC/AJCC 2010 Stage T1-4 N0-3 M0
Male or female patients with age between 18 and 75 years old
Karnofsky Performance Scores 60
Expected survival 3 months
Without dysfunction of heart, lung, liver, kidney and hematopoiesis

Exclusion Criteria

Karnofsky Performance Status Score < 70'
Radiotherapy uncompleted ( 1 fraction missing)
Distant metastases before or during radiotherapy
Without weekly complete blood count during radiotherapy
Application of colony stimulating factor such as erythropoietin
Signs of infection before radiotherapy
Clear my responses

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