Last updated on May 2019

Study Investigating the Cardiotoxicity of Anthracyclines in Patients With Diffuse Large B-Cell

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Large B-Cell | Lymphoma | Diffuse Large B-Cell
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Histologically confirmed Diffuse Large B-Cell Lymphoma diagnosis
  • Patient eligible to receive 6 cycles of R-CHOP or R-CHOP like chemotherapy at full doses
  • Age 18
  • Stage I-IV
  • Written informed consent
  • ECOG Performance Status 0-3
  • Ventricular Ejection Fraction (VEF) 40%
  • No previous treatment for lymphoma (except for RT-IF)
  • Negative -HCG pregnancy test result at diagnosis for female of childbearing potential
  • Use of acceptable method of contraception during the study and for 3 months after receiving the last dose of study drug for patients with childbearing potential
  • Availability of the patient to be followed for all the phases of the chemotherapy treatment and for the subsequent follow-up

Exclusion Criteria:

  • Inability to schedule a treatment at full doses of chemoimmunotherapy R-CHOP or R-CHOP-like for different reasons
  • Central nervous system involvement due to lymphoma
  • HIV
  • Active cardiac pathology including heart failure, left ventricular dysfunction documented by a LVEF <40%, arrhythmias (rapid atrial fibrillation, frequent ventricular arrhythmias), valvular aortic or mitral disfunction > moderate, ischemic heart disease (myocardial infarction or acute coronary syndrome for over 6 months, angina at rest or with mild efforts)
  • Previous treatment for lymphoma
  • Other malignancy in the 3 years prior to the diagnosis of lymphoma with exception of non-melanoma skin cancer or in situ carcinoma
  • Any other co-existing medical condition that would preclude participation in the study (uncontrolled bacterial or viral or fungal infection)
  • Pregnant, or lactating and breastfeeding female

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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