Last updated on February 2019

Urinary Tract Infection Due to Beta-lactamase-producing Enterobacteriaceae in Children


Brief description of study

Urinary tract infection due to Extended-spectrum beta-lactamase producing enterobacteriaceae (E-ESBL UTI) become a frequent problem. A too large variety in the prescription of antibiotics for E-ESBL UTI in children and absolute recommendations regarding the optimal treatment of E-ESBL is nearly impossible at this time.

Our aim was to describe the characteristics and treatments of urinary tract infections caused by Extended spectrum betalactamase-producing Enterobacteriaceae in children.

Detailed Study Description

In this prospective observational study between March 2013 and March 2017, children (0 to 18 years) with ESBL-E UTI were enrolled in 24 pediatric departments in France. Clinical and biological characteristics, risk factors of infection of E-ESBL, first and second lines of antibiotic therapies were analyzed. The investigators used the Kaplan-Meier method to estimate the time to fever defervescence and hospitalization duration, and Log-rank test to assess equality of survivor functions. The investigators also analyzed the resistance patterns and molecular characterization of ESBL types in the isolates.

Clinical Study Identifier: NCT02832258

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bogdan cojocaru

Louis Mourier Hospital
Colombes, France
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Valerie Soussan-banini

Hopital Ambroise Par
Boulogne-Billancourt, France
5.72miles
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Vincent Gadjos

Antoine Becl re Hospital
Clamart, France
8.45miles
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Marie-Aliette Dommergues

Andr Mignot Hospital
Le Chesnay, France
8.7miles
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Irina Craiu

CHU Le Kremlin-Bic tre
Kremlin-Bicètre, France
9.06miles
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Recruitment Status: Open


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