Ro Plus CHOEP as First Line Treatment Before HSCT in Young Patients With Nodal Peripheral T-cell Lymphomas

  • STATUS
    Not Recruiting
  • End date
    Mar 23, 2027
  • participants needed
    110
  • sponsor
    Fondazione Italiana Linfomi ONLUS
Updated on 24 March 2021
Investigator
Sonia Perticone, PhD
Primary Contact
IRCCS Casa Sollievo Della Sofferenza (0.0 mi away) Contact
+36 other location

Summary

This is a multicenter study that includes two phases:

  1. A phase I study to define the maximum tolerated dose (MTD) of Romidepsin in addition to CHOEP-21 and to test the safety and feasibility of CHOEP-21 in combination with dose escalation of Romidepsin (8, 10, 12, 14 mg). The dose level defined as MTD of Romidepsin will be used for the subsequent phase II study.
  2. A phase II study to evaluate the efficacy (response rate, progression free survival and overall survival) and safety of Ro-CHOEP-21 incorporated into a treatment strategy including SCT.

Details
Condition Peripheral T-Cell Lymphoma, Angioimmunoblastic Lymphadenopathy, ALK- Anaplastic Large Cell Lymphoma (ALCL), ALK- Anaplastic Large Cell Lymphoma (ALCL), ALK- Anaplastic Large Cell Lymphoma (ALCL), Nodal Peripheral T-Cell Lymphoma of T Follicular Helper Cell Origin
Treatment Ro-CHOEP-21 (PHASE I), Ro-CHOEP-21 (PHASE II)
Clinical Study IdentifierNCT02223208
SponsorFondazione Italiana Linfomi ONLUS
Last Modified on24 March 2021

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