Cardiovascular Effects of Preferred Home-based Exercise Training in Systolic Heart Failure

  • days left to enroll
  • participants needed
  • sponsor
    University Medicine Greifswald
Updated on 8 October 2021
medical therapy
ejection fraction
systolic heart failure


The aim of the study is I. To assess whether an individualized exercise training program is superior as compared to usual care with respect to exercise tolerance, II. to assess whether intervention tools that aim to increase exercise adherence are superior to an individualized exercise training alone with respect to exercise tolerance and long-term effects, and III. to identify biomarkers that that may be implemented into novel intervention tools aiming to increase exercise adherence in patients with chronic heart failure.

Condition Chronic Heart Failure
Treatment exercise training, Adherence measures
Clinical Study IdentifierNCT02051712
SponsorUniversity Medicine Greifswald
Last Modified on8 October 2021


Yes No Not Sure

Inclusion Criteria

women and men
age 30-75 years
chronic heart failure (NYHA II/III), left ventricular ejection fraction 40% be echo
disease duration 6 month
medical therapy accruing to guidelines (drug, devices, including CRT)
written informed consent

Exclusion Criteria

acute myocarditis
instable angina
heart surgery (e.g. ICD implantation, bypass) with last 6 weeks; CRT implantation within the last 6 months before study start
severe cardiovascular events (myocardial infarction, cardiac decompensation, ICD shock, PCI due to instable angina) < 6 weeks before study start
preplanned hospital admission or intervention (e.g. planned revascularization, ICD implantation)
uncorrected valve regurgitation or stenosis (> second degree)
safety concerns regarding or other reasons against exercise training
severe depression
regular exercise training within the last 6 weeks
life expectancy < 1 year
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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