Total Marrow and Lymphoid Irradiation and Chemotherapy for High-Risk Acute Leukemia

  • participants needed
  • sponsor
    Affiliated Hospital to Academy of Military Medical Sciences
Updated on 30 January 2023
myeloid leukemia
total body irradiation
blood stem cell transplant
carbon monoxide
ejection fraction
lymphocytic leukemia


RATIONALE: Giving chemotherapy and total marrow and lymphoid irradiation before allogeneic hematopoietic cell transplant helps stop the growth of leukemia cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may achieve brand new hematopoietic recovery. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells, resulting in graft versus-host disease.

PURPOSE: This study is to evaluate the toxicity and efficacy of total marrow and lymphoid irradiation conditioning when given together with combination chemotherapy and allogeneic peripheral blood stem cell transplant in treating patients with high-risk acute leukemia.


Patient receives preparative therapy including cyclophosphamide and total body irradiation (TBI) of 10 Gy or total marrow and lymphoid irradiation (TMLI) of 12-20 Gy, and starts immunosuppressive therapy using cyclosporine or tacrolimus, methotrexate-based prophylaxes, followed by peripheral blood stem cell transplantation and granulocyte colony-stimulating factor administration.

Condition Acute Leukemia, acute leukemias
Treatment Total body irradiation, total marrow and lymphoid irradiation
Clinical Study IdentifierNCT03408223
SponsorAffiliated Hospital to Academy of Military Medical Sciences
Last Modified on30 January 2023

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