Improving Bi-manual Activities in Stroke Patients With Application of Neuro-stimulation

  • End date
    Dec 13, 2030
  • participants needed
  • sponsor
    University Hospital of Mont-Godinne
Updated on 13 May 2021
transcranial direct current stimulation
chronic stroke


Noninvasive brain stimulations (NIBS) will be used in healthy volunteers and in chronic stroke patients to improve bimanual activities and motor learning.

Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying bimanual activities and motor learning in healthy volunteers and in chronic stroke patients.

A neuro-rehabilitation robot (REA2PLAN, AXINESIS, Louvain-la-Neuve, Belgium) will be used for motor learning.


tDCS will be used in a sham-controlled, double-blind, randomized, cross-over control trial in chronic stroke patients with motor deficits. After informed consent and recruitment, patients will be randomly (computer method) allocated to real or sham tDCS, that will be applied during performance of bimanual activities and/or motor learning. A few minutes/hours/days/weeks after completing one trial's arm, the patients will enter the other trial's arm (double-blind cross-over design).

Baseline and follow-up outcomes about bimanual and unimanual motor tasks will be collected.

For a subset of subjects, motor learning and data acquisition will be performed with a neuro-rehabilitation robot (REA2PLAN, AXINESIS, Louvain-la-Neuve, Belgium) .

Condition Cerebrovascular accident, Stroke, Deficit in Manual Activities, Stroke, cerebrovascular accidents, strokes, cerebral
Treatment tDCS
Clinical Study IdentifierNCT02308852
SponsorUniversity Hospital of Mont-Godinne
Last Modified on13 May 2021


Yes No Not Sure

Inclusion Criteria

stroke with at least slight deficit

Exclusion Criteria

contraindication to tDCS and/or to fMRI
presence of metal in the head
inability to understand / complete behavioral tasks
chronic intake of alcohol or recreational drugs
major health condition
presence of pacemaker (for the fMRI part only)
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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