Focal Brachytherapy in Patients With Selected "Low-risk" Prostate Cancer - a Phase-II-trial

  • End date
    Dec 21, 2029
  • participants needed
  • sponsor
    University of Erlangen-Nürnberg Medical School
Updated on 21 January 2021


This trial examines the feasibility and toxicity of focal brachytherapy in patients with low-risk prostate cancer.


Patients with low-risk prostate cancer will receive HDR-Brachytherapy: 2 x 13,5 Gy.

Condition Malignant neoplasm of prostate, Prostate Cancer, Prostate Cancer, Early, Recurrent, Prostatic disorder, Prostate Disorders, Prostate Disorders, Prostate Cancer, Early, Recurrent, Prostate Cancer, prostate carcinoma, prostate cancers
Treatment HDR-Brachytherapy
Clinical Study IdentifierNCT02391051
SponsorUniversity of Erlangen-Nürnberg Medical School
Last Modified on21 January 2021


Yes No Not Sure

Inclusion Criteria

Age > 18
Histologically confirmed prostate cancer
Gleason Score of index lesion 6 (3+3)
Tumor stage: cT1-2a cN0 cM0
Unilateral affection; index lesion 0.5ml with or without clinically non-significant lesion contralateral. No more than 25% of the punch should be affected. Therefore a 3D-TPM-biopsy is mandatory before treatment
PSA 10/ng/ml
Prostate volume < 60 m^3
No distant metastasis
Life expectancy > 10 years
Informed consent

Exclusion Criteria

Tumor stage T2b
Known metastasis: N+ and/or M1
General anesthesia or peridural anesthesia is not possible
Coagulation disorder
Clear my responses

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