Role of Fcgamma Receptors in Immune Thrombocytopenia (ITP)

  • STATUS
    Recruiting
  • End date
    Sep 1, 2024
  • participants needed
    70
  • sponsor
    Centre Hospitalier Universitaire Dijon
Updated on 1 July 2021
thrombocytopenia
autoimmune disease
arthritis
lupus
autoimmune thrombocytopenia

Summary

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a peripheral destruction of platelets responsible for bleedings.

Monocytes/macrophages play a double role by phagocyting platelets recognized by autoantibodies and by maintaining the autoimmune response via their antigen-presenting cell functions.

Fcgamma receptors (FcR), that are represented by activating receptors (FcRI, FcRIIa, FcRIII) and an inhibiting one (FcRIIb), are involved in the regulation of macrophages and have been reported to be dysregulated in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematous.

The aim of this study is to compare the expression of FcR in patients with ITP on circulating monocytes and on splenic macrophages.

Details
Condition Purpura Immunological Thrombopenia (PTI), IDIOPATHIC THROMBOCYTOPENIC PURPURA, Thrombocytopenic, Immune Thrombocytopenia, Idiopathic Thrombocytopenic Purpura (ITP), Autoimmune Disease, Autoimmune disease, autoimmune thrombocytopenia
Treatment Blood sample, spleen sample
Clinical Study IdentifierNCT02821572
SponsorCentre Hospitalier Universitaire Dijon
Last Modified on1 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

ITP group
Patients who have provided written consent
Patients over 18 years
Patients with national health insurance
Patients with ITP, defined as thrombocytopenia < 100 G/L, after exclusion of infection- or drug-related thrombocytopenia and malignant hemopathy
Control Group
Persons who have provided a written consent
Persons over 18 years
Persons with national health insurance
Persons without autoimmune disease

Exclusion Criteria

Patients under guardianship
Pregnancy
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