Role of Fcgamma Receptors in Immune Thrombocytopenia (ITP)
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- STATUS
- Recruiting
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- End date
- Sep 1, 2024
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- participants needed
- 70
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- sponsor
- Centre Hospitalier Universitaire Dijon
Summary
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a peripheral destruction of platelets responsible for bleedings.
Monocytes/macrophages play a double role by phagocyting platelets recognized by autoantibodies and by maintaining the autoimmune response via their antigen-presenting cell functions.
Fcgamma receptors (FcR), that are represented by activating receptors (FcRI, FcRIIa, FcRIII) and an inhibiting one (FcRIIb), are involved in the regulation of macrophages and have been reported to be dysregulated in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematous.
The aim of this study is to compare the expression of FcR in patients with ITP on circulating monocytes and on splenic macrophages.
Details
| Condition | Purpura Immunological Thrombopenia (PTI), IDIOPATHIC THROMBOCYTOPENIC PURPURA, Thrombocytopenic, Immune Thrombocytopenia, Idiopathic Thrombocytopenic Purpura (ITP), Autoimmune Disease, Autoimmune disease, autoimmune thrombocytopenia |
|---|---|
| Treatment | Blood sample, spleen sample |
| Clinical Study Identifier | NCT02821572 |
| Sponsor | Centre Hospitalier Universitaire Dijon |
| Last Modified on | 1 July 2021 |
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