Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease

  • End date
    Dec 28, 2022
  • participants needed
  • sponsor
    Cedars-Sinai Medical Center
Updated on 28 August 2021


Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women. There are an estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent data from our research group suggests that coronary microvascular disease impairs the way the heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to better understand the pathophysiology of the disease. The investigators will recruit 30 volunteers total (10 healthy calibration subjects, 10 women with microvascular disease, and 10 age-match women for the group with microvascular disease). Subjects will undergo a series of "stress" maneuvers in conjunction with advanced cardiac magnetic resonance imaging.

Condition Microvascular Coronary Dysfunction
Treatment Handgrip, Altitude simulation, Leg exercise
Clinical Study IdentifierNCT02301663
SponsorCedars-Sinai Medical Center
Last Modified on28 August 2021


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Inclusion Criteria

Fully understanding and willing to undergo study procedures
Male or Female greater than or equal to 18 years of age
Understanding and willing to sign consent form

Exclusion Criteria

History of cardiovascular, pulmonary, or neurological disease
Hypertension (sitting blood pressure >140/90 mmHg, with measurements recorded on at least 2 occasions)
Unable to give informed consent
Contra-indication to CMRI testing, including claustrophobia and metallic implants
Adherence or retention issues
Women who are pregnant
Allergy to animal dander
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