Last updated on June 2005

International Registry for Severe Chronic Neutropenia


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Neutropenia
  • Age: Between 1 - 100 Years
  • Gender: Male or Female
  • Other:
    -Disease Characteristics-- Severe chronic neutropenia (SCN), i.e.: Absolute neutrophil
    count less than 500/mm3 on 3 occasions within the last 3 months (less than 200/mm3 for
    cyclic neutropenia) Bone marrow aspirate consistent with SCN History of infection No drug
    induced neutropenia No myelodysplastic syndrome No aplastic anemia No thrombocytopenia or
    anemia unless due to Shwachman-Diamond syndrome or glycogen storage disease type IB Prior
    enrollment on Amgen SCN trials eligible Bone marrow aspiration within 1 year required
    Cytogenetic evaluation strongly suggested --Prior/Concurrent Therapy-- At least 5 years
    ince prior chemotherapy --Patient Characteristics-- No rheumatoid arthritis No systemic
    lupus erythematosus No HIV seropositivity
    -Disease Characteristics-- Severe chronic neutropenia (SCN), i.e.: Absolute neutrophil
    count less than 500/mm3 on 3 occasions within the last 3 months (less than 200/mm3 for
    cyclic neutropenia) Bone marrow aspirate consistent with SCN History of infection No drug
    induced neutropenia No myelodysplastic syndrome No aplastic anemia No thrombocytopenia or
    anemia unless due to Shwachman-Diamond syndrome or glycogen storage disease type IB Prior
    enrollment on Amgen SCN trials eligible Bone marrow aspiration within 1 year required
    Cytogenetic evaluation strongly suggested --Prior/Concurrent Therapy-- At least 5 years
    ince prior chemotherapy --Patient Characteristics-- No rheumatoid arthritis No systemic
    lupus erythematosus No HIV seropositivity
    -Disease Characteristics-- Severe chronic neutropenia (SCN), i.e.: Absolute neutrophil
    count less than 500/mm3 on 3 occasions within the last 3 months (less than 200/mm3 for
    cyclic neutropenia) Bone marrow aspirate consistent with SCN History of infection No drug
    induced neutropenia No myelodysplastic syndrome No aplastic anemia No thrombocytopenia or
    anemia unless due to Shwachman-Diamond syndrome or glycogen storage disease type IB Prior
    enrollment on Amgen SCN trials eligible Bone marrow aspiration within 1 year required
    Cytogenetic evaluation strongly suggested --Prior/Concurrent Therapy-- At least 5 years
    ince prior chemotherapy --Patient Characteristics-- No rheumatoid arthritis No systemic
    lupus erythematosus No HIV seropositivity
    -Disease Characteristics-- Severe chronic neutropenia (SCN), i.e.: Absolute neutrophil
    count less than 500/mm3 on 3 occasions within the last 3 months (less than 200/mm3 for
    cyclic neutropenia) Bone marrow aspirate consistent with SCN History of infection No drug
    induced neutropenia No myelodysplastic syndrome No aplastic anemia No thrombocytopenia or
    anemia unless due to Shwachman-Diamond syndrome or glycogen storage disease type IB Prior
    enrollment on Amgen SCN trials eligible Bone marrow aspiration within 1 year required
    Cytogenetic evaluation strongly suggested --Prior/Concurrent Therapy-- At least 5 years
    ince prior chemotherapy --Patient Characteristics-- No rheumatoid arthritis No systemic
    lupus erythematosus No HIV seropositivity
    -Disease Characteristics-- Severe chronic neutropenia (SCN), i.e.: Absolute neutrophil
    count less than 500/mm3 on 3 occasions within the last 3 months (less than 200/mm3 for
    cyclic neutropenia) Bone marrow aspirate consistent with SCN History of infection No drug
    induced neutropenia No myelodysplastic syndrome No aplastic anemia No thrombocytopenia or
    anemia unless due to Shwachman-Diamond syndrome or glycogen storage disease type IB Prior
    enrollment on Amgen SCN trials eligible Bone marrow aspiration within 1 year required
    Cytogenetic evaluation strongly suggested --Prior/Concurrent Therapy-- At least 5 years
    ince prior chemotherapy --Patient Characteristics-- No rheumatoid arthritis No systemic
    lupus erythematosus No HIV seropositivity
    -Disease Characteristics-- Severe chronic neutropenia (SCN), i.e.: Absolute neutrophil
    count less than 500/mm3 on 3 occasions within the last 3 months (less than 200/mm3 for
    cyclic neutropenia) Bone marrow aspirate consistent with SCN History of infection No drug
    induced neutropenia No myelodysplastic syndrome No aplastic anemia No thrombocytopenia or
    anemia unless due to Shwachman-Diamond syndrome or glycogen storage disease type IB Prior
    enrollment on Amgen SCN trials eligible Bone marrow aspiration within 1 year required
    Cytogenetic evaluation strongly suggested --Prior/Concurrent Therapy-- At least 5 years
    ince prior chemotherapy --Patient Characteristics-- No rheumatoid arthritis No systemic
    lupus erythematosus No HIV seropositivity
    -Disease Characteristics-- Severe chronic neutropenia (SCN), i.e.: Absolute neutrophil
    count less than 500/mm3 on 3 occasions within the last 3 months (less than 200/mm3 for
    cyclic neutropenia) Bone marrow aspirate consistent with SCN History of infection No drug
    induced neutropenia No myelodysplastic syndrome No aplastic anemia No thrombocytopenia or
    anemia unless due to Shwachman-Diamond syndrome or glycogen storage disease type IB Prior
    enrollment on Amgen SCN trials eligible Bone marrow aspiration within 1 year required
    Cytogenetic evaluation strongly suggested --Prior/Concurrent Therapy-- At least 5 years
    ince prior chemotherapy --Patient Characteristics-- No rheumatoid arthritis No systemic
    lupus erythematosus No HIV seropositivity

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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