Last updated on February 2019

Dextromethorphan in Chemotherapy-induced Peripheral Neuropathy Management


Brief description of study

The aim of this study is to assess if dextromethorphan administered during 4 weeks induces a decrease of pain intensity in breast cancer patients suffering from chemotherapy-induced peripheral neuropathy compared to placebo group.

Detailed Study Description

This is a randomized, placebo-controlled, double-blind, parallel-group clinical trial comparing dextromethorphan and placebo for the treatment of chemotherapy-induced peripheral neuropathy, assessed with a (0-10) numerical scale. Cognition, anxiety, depression, sleep and quality of life are also assessed.

The influence of CYP2D6, CYP3A4 and MDR1 polymorphism on the dextromethorphan analgesic efficacy will be measured.

Clinical Study Identifier: NCT02271893

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CHU de Clermont-Ferrand

Clermont-Ferrand, France
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Recruitment Status: Open


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