Last updated on February 2018

Metformin and Dietary Restriction to Prevent Age-related Morbid Events in People With Metabolic Syndrome

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Metabolic syndrome
  • Age: Between 55 - 74 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Age 55-74, waist circumference equal or greater than 85 cm for women and 100 cm for men, plus at least two other factors among those defining the MetS

Exclusion Criteria:

  • Diagnosed diabetes (or baseline fasting glycemia above 7mmol/L at baseline examination)
  • Cancer (except skin carcinoma) diagnosed in the last 5 years, or under treatment
  • Excessive frailty: in absence of agreed-upon measurements parameters and cutoff points, the investigator will exclude subjects under the lower 5th percentile of the muscular mass distribution estimated by impedance in previous studies
  • Conditions that contraindicate the use of MET because might favour lactic acidosis:
  • Renal, cardiac, hepatic, or respiratory insufficiency
  • Serum creatinine <124mol/L, or proteinuria at baseline examination
  • Current treatment with K-sparing diuretics, or with proton pump inhibitors
  • Excessive alcohol consumption
  • Distressing side effects of MET treatment. Nausea and diarrhoea typically occur in about one third of patients receiving MET for the first time at full dose. To avoid dropouts for gastrointestinal discomfort we will treat all volunteers with half the planned dose for one month in order to exclude intolerant subjects before randomization. Participants randomized in the intervention group will continue to take half a dose for one month and then shift to the full dose.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.