Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury

  • STATUS
    Recruiting
  • End date
    Dec 24, 2021
  • participants needed
    24
  • sponsor
    University of Manitoba
Updated on 24 January 2021
haemostasis
treatment of burn

Summary

The standard of care for treatment of burn injury is to inject a solution of epinephrine under the skin of the injured site in order to reduce blood loss during skin grafting. This solution of epinephrine has been shown to have effects on the body outside the donor site. Some people have increases in heart rate and blood pressure. We will study the effect of a phenylephrine solution in place of an epinephrine solution to control blood loss. We think that phenylephrine will help decrease blood loss and not change blood pressure or heart rate.

The injured area will be injected under the skin and a skin graft will be taken in the same way as we usually do. The only change will be the use of phenylephrine in the solution instead of epinephrine.

Our goal is to find whether or not phenylephrine or epinephrine solution results in a reduction of blood loss without affecting the rest of the body.

Details
Condition Intraoperative hemorrhage
Treatment Phenylephrine
Clinical Study IdentifierNCT01731444
SponsorUniversity of Manitoba
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 75 yrs?
Gender: Male or Female
Do you have Intraoperative hemorrhage?
Do you have any of these conditions: Do you have Intraoperative hemorrhage??
Burn injury requiring debridement and grafting between 5-30% TBSA

Exclusion Criteria

Head and neck, hand, foot, or genital burns
On anticoagulants (except NSAIDs)
On monoamine oxidase inhibitor or tricyclic antidepressant
Coronary or peripheral vascular disease
History of arrhythmias
On a Beta-blocker
History of vascular abnormality
Hypertension
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