The Effect in Wedge Resection and IVb/V Resection of the Liver for Gallbladder Cancer

  • STATUS
    Recruiting
  • participants needed
    88
  • sponsor
    Saint Vincent's Hospital, Korea
Updated on 21 January 2021

Summary

The extent of hepatic resection for gallbladder cancer can be done from a wedge resection to 4b/5 bisegmentectomy. This study aims to compare the recurrence rates and survival rates between wedge resection group and bisegmentectomy group. Patients with T2 or T3 gallbladder cancer on preoperative CT exam or patients who were pathologically diagnosed as T2 or T3 gallbladder cancer after initial simple cholecystectomy were enrolled. All patients are randomly assigned to wedge resection or bisegmentectomy group. Number of patients in each group is 44. Primary endpoint is recurrence-free-survival rates and overall survival rates.

Description

The extent of hepatic resection for gallbladder cancer has a wide range. A partial hepatectomy involving the gallbladder fossa is a critical part of the resection but can range from a wedge resection to an anatomic resection of segments 4b and 5 to an extended right hepatectomy. This study enrolls Patients with T2 or T3 gallbladder cancer on preoperative CT exam or patients who were pathologically diagnosed as T2 or T3 gallbladder cancer after initial simple cholecystectomy. Eighty eight patients are randomized to wedge resection group or bisegmentectomy group. Except the extent of hepatic resection, all the procedures including hepatoduodenal,common hepatic, posterior pancreatic lymph node dissection are same.

Primary endpoint is recurrence-free-survival rates and overall survival rates.

Details
Condition Biliary neoplasm, Malignant neoplasm of gallbladder, Gallbladder Disease, Gallbladder Carcinoma, Urothelial Tract Cancer, Gall Bladder Disorders, Gall Bladder Cancer, Biliary Tract Cancer, gallbladder cancer
Treatment Wedge resection, bisegmentectomy
Clinical Study IdentifierNCT02920554
SponsorSaint Vincent's Hospital, Korea
Last Modified on21 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with T2 or T3 gallbladder cancer on preoperative CT exam
Patients who are pathologically diagnosed as T2 or T3 gallbladder cancer after initial simple cholecystectomy

Exclusion Criteria

Peritoneal seeding or distant metastasis
Impossible to resect the cancer radically
Pathologically diagnosed to other malignancy such as adenosquamous carcinoma, sarcoma, etc
R1 or R2 resection were pathologically diagnosed
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