Super-Selective Intraarterial Intracranial Infusion of Bevacizumab (Avastin) for Glioblastoma Multiforme

  • participants needed
  • sponsor
    Global Neurosciences Institute
Updated on 27 June 2022
intraarterial cerebral infusion
karnofsky performance status
complete resection
brain tumor
beam radiation
malignant brain tumor
primary brain tumors


The high-grade malignant brain tumor glioblastoma multiforme (GBM) comprise the majority of all primary brain tumors in adults. This group of tumors also exhibits the most aggressive behavior, resulting in median overall survival durations of only 9-12 months for GBM. Initial therapy consists of surgical resection, external beam radiation or both. Currently, all patients experience a recurrence after this first-line therapy, so improvements in both first-line and salvage therapy are critical to enhancing quality-of-life and prolonging survival. Superselective Intraarterial Cerebral Infusion (SIACI) is a technique that can effectively increase the concentration of drug delivered to the brain while sparing the body of systemic side effects. This technique threads a tiny catheter through the patient's femoral artery in the leg, up through the body and neck and into the brain. Once the catheter reaches the brain, chemotherapy is released to the blood vessels that feed the tumor.

Condition Glioblastoma Multiforme, Glioblastoma Multiforme, glioblastoma
Treatment bevacizumab
Clinical Study IdentifierNCT02285959
SponsorGlobal Neurosciences Institute
Last Modified on27 June 2022

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