A Prospective Study of Plasma Genotyping as a Noninvasive Biomarker for Genotype-directed Cancer Care

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    Dana-Farber Cancer Institute
Updated on 12 March 2022
systemic therapy
lung cancer
targeted therapy
advanced lung cancer
advanced melanoma
lung carcinoma
immunologic adjuvant
braf v600e mutation
egfr t790m


Tumor genotyping has become an essential biomarker for the care of advanced lung cancer and melanoma, and is currently used to identify patients for treatment with targeted kinase inhibitors like erlotinib and vemurafenib. However, tumor genotyping can be slow and cumbersome, and is limited by availability of tumor biopsy tissue for testing. The aim of this study is to prospectively evaluate a blood-based genotyping tool that can quantify the presence of oncogenic mutations (EGFR, KRAS, BRAF) in patients with lung cancer and melanoma. This assay is being studied both as a diagnostic tool for classifying patient genotype, and a serial measurement tool for quantification of response and progression on therapy.

Condition NSCLC, Melanoma
Clinical Study IdentifierNCT02279004
SponsorDana-Farber Cancer Institute
Last Modified on12 March 2022


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