Study of Chemotherapy Plus Icotinib to Treat EGFR Mutation-positive Non-small-cell Lung Cancer

  • participants needed
  • sponsor
    Nanfang Hospital of Southern Medical University
Updated on 8 November 2020
growth factor
epidermal growth factor receptor
cancer chemotherapy
epidermal growth factor
lung carcinoma


Non-small-cell lung cancer (NSCLC) patients with activating epidermal growth factor receptor (EGFR) mutations are exquisitely sensitive to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) which is widely used in advanced patients. Whether treatment with EGFR-TKIs improves outcomes in patients with resected NSCLC harboring EGFR mutations is still under investigated. This study aims to observe and compare the efficacy and safety of intercalated combination of chemotherapy plus icotinib in patients undergoing resection of EGRF mutation-positive non-small cell lung cancer stagingB (with high risk factor) to A.

Condition Non-Small Cell Lung Cancer
Treatment Icotinib
Clinical Study IdentifierNCT02272127
SponsorNanfang Hospital of Southern Medical University
Last Modified on8 November 2020


Yes No Not Sure

Inclusion Criteria

Patients undergoing completely resection of EGRF mutation-positive NSCLC
Staging B (with high risk factor) to A
Adequate hematological, biochemical and organ functions

Exclusion Criteria

Systemic anticancer therapy prior to surgery, other malignancies before or during the study, any unstable illness, women who were pregnant or lactating
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