MSC Therapy in Liver Transplantation

  • End date
    Oct 22, 2025
  • participants needed
  • sponsor
    Monia Lorini
Updated on 22 January 2021


The general aim of the present study is to test a cell therapy with third-party allogeneic ex-vivo expanded MSCs as a strategy to induce tolerance in liver transplant recipients. MSCs will be prepared accordingly to established protocols , starting from diagnostic samples of bone marrow aspirates (2-5 mL) or using the remnants in the bag and filter at the end of the bone marrow infusions. From these samples, MSCs will be expanded in GMP approved facilities and used for the present study in patients undergoing liver transplantation.

Condition Liver Transplant Rejection
Treatment mesenchymal stromal cells
Clinical Study IdentifierNCT02260375
SponsorMonia Lorini
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

For this study, the following inclusion criteria should be fulfilled before
starting withdrawal of drugs after 1 year post-transplant
First liver transplant
Capable of understanding the purpose and risk of the study
Written informed consent

Exclusion Criteria

Specific contraindication to MSC infusion
Any clinical relevant condition that might affect study participation and/or study results
Pregnant women and nursing mothers
Unwillingness or inability to follow the study protocol in the investigator's opinion
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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