MSC Therapy in Liver Transplantation

  • STATUS
    Recruiting
  • End date
    Oct 22, 2025
  • participants needed
    20
  • sponsor
    Monia Lorini
Updated on 22 January 2021

Summary

The general aim of the present study is to test a cell therapy with third-party allogeneic ex-vivo expanded MSCs as a strategy to induce tolerance in liver transplant recipients. MSCs will be prepared accordingly to established protocols , starting from diagnostic samples of bone marrow aspirates (2-5 mL) or using the remnants in the bag and filter at the end of the bone marrow infusions. From these samples, MSCs will be expanded in GMP approved facilities and used for the present study in patients undergoing liver transplantation.

Details
Condition Liver Transplant Rejection
Treatment mesenchymal stromal cells
Clinical Study IdentifierNCT02260375
SponsorMonia Lorini
Last Modified on22 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

For this study, the following inclusion criteria should be fulfilled before
starting withdrawal of drugs after 1 year post-transplant
First liver transplant
Capable of understanding the purpose and risk of the study
Written informed consent

Exclusion Criteria

Specific contraindication to MSC infusion
Any clinical relevant condition that might affect study participation and/or study results
Pregnant women and nursing mothers
Unwillingness or inability to follow the study protocol in the investigator's opinion
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note