Exploratory Next Generation Sequencing to Identify Causative Variants for Therapy-Induced Congestive Heart Failure From Breast Cancer Study E5103 Germline DNA Samples
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- STATUS
- Recruiting
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- End date
- Jan 1, 2100
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- participants needed
- 162
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- sponsor
- National Cancer Institute (NCI)
Summary
This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with congestive heart failure receiving therapy for breast cancer. Studying samples of germline DNA in the laboratory from patients with congestive heart failure receiving therapy for breast cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to congestive heart failure.
Description
PRIMARY OBJECTIVES:
I. To identify, using next generation sequencing, rare variants of large effect size that impact the risk of congestive heart failure (CHF) in patients from the clinical trial ECOG-5103 (E5103).
- OUTLINE
Previously collected germline DNA samples are analyzed via whole exome sequencing.
Details
| Condition | Breast Carcinoma |
|---|---|
| Treatment | laboratory biomarker analysis |
| Clinical Study Identifier | NCT02610426 |
| Sponsor | National Cancer Institute (NCI) |
| Last Modified on | 24 October 2022 |
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