Use of Warfarin After the First Trimester in Pregnant Women With APS

  • STATUS
    Recruiting
  • End date
    Jul 24, 2021
  • participants needed
    100
  • sponsor
    Mohamed Sayed Abdelhafez
Updated on 24 January 2021
heparin
warfarin
vitamin k antagonist
enoxaparin
vitamin
early pregnancy
antiphospholipid syndrome

Summary

Evaluation of shifting to oral vitamin K antagonist after the first trimester instead of using low molecular weight heparin (LMWH) throughout pregnancy in pregnant women with antiphospholipid syndrome (APS)

Description

Women will be randomly divided into two groups; one will be subjected to anticoagulant therapy by Enoxaparin throughout pregnancy and the other will be subjected to anticoagulant therapy by Enoxaparin in the first trimester then Warfarin after the first trimester until termination of pregnancy.

Details
Condition Antiphospholipid Syndrome, Autoimmune disease, habitual abortion, Spontaneous abortion, Miscarriage, recurrent miscarriage, recurrent abortions
Treatment Warfarin, Enoxaparin
Clinical Study IdentifierNCT02303171
SponsorMohamed Sayed Abdelhafez
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 20 yrs and 38 yrs?
Are you female?
Do you have any of these conditions: Miscarriage or recurrent miscarriage or Spontaneous abortion or recurrent abortions or Autoimmune disease or habitual abortion or Antiphospholipid Syn...?
Pregnant women with APS diagnosed according to the revised classification criteria for APS in 2006 in Sydney, Australia
Early pregnancy body weight is 50-90 Kg

Exclusion Criteria

Women with systemic lupus erythematosus (SLE)
Women with active thromboembolic disorders
Women with history of previous thromboembolic disorders
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